{"created":"2023-06-19T12:05:26.327640+00:00","id":166,"links":{},"metadata":{"_buckets":{"deposit":"3c6f7322-0528-456b-9dfc-485948d7568c"},"_deposit":{"created_by":15,"id":"166","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"166"},"status":"published"},"_oai":{"id":"oai:u-nagano.repo.nii.ac.jp:00000166","sets":["6:17"]},"author_link":["457","654","759","758","653","760","652"],"item_3_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-02","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"27","bibliographicPageStart":"23","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"長野県短期大学紀要"},{"bibliographic_title":"Journal of Nagano Prefectural College","bibliographic_titleLang":"en"}]}]},"item_3_description_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_description":"120005280228","subitem_description_type":"Other"}]},"item_3_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The importance of apoptosis response on cancer cells has become a focal point of cancer research. However, little information is available on the apoptotic effects of aminolevulinic acid （ALA）. The purpose of this study was to explore the influence of ALA on HepG2 cell proliferation. HepG2 cells were cultivated for four days in media supplemented with ALA （ALA+） and without ALA （ALA-）. Phase contrast micrographs were taken every day, and the number of cells was counted. Cytochrome C oxidase activity was analyzed in the mitochondrial membrane, as well as outside the membrane. Compared with ALA-, ALA+ showed suppression of HepG2 cell proliferation and increased cytochrome C oxidase activity outside the mitochondrial membrane. The present results suggest that ALA elevate apoptosis by increasing release of cytochrome C from mitochondria.","subitem_description_type":"Abstract"}]},"item_3_full_name_23":{"attribute_name":"著者名（英）","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"758","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yokoyama, Meiko","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"759","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Izumi, Yoshiya","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"760","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tanaka, Toru","nameLang":"en"}]},{"nameIdentifiers":[{"nameIdentifier":"457","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000060170875","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}],"names":[{"name":"Shizuka, Fujiko","nameLang":"en"}]}]},"item_3_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"長野県短期大学"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00179035","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0286-1178","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"横山, 芽衣子"},{"creatorName":"ヨコヤマ, メイコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"652","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000238400079","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000238400079"}]},{"creatorNames":[{"creatorName":"泉, 可也"},{"creatorName":"イズミ, ヨシヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"653","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 徹"},{"creatorName":"タナカ, トオル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"654","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"志塚, ふじ子"},{"creatorName":"シズカ, フジコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"457","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000060170875","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-03-21"}],"displaytype":"detail","filename":"紀要67-03.pdf","filesize":[{"value":"329.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"紀要67-03","url":"https://u-nagano.repo.nii.ac.jp/record/166/files/紀要67-03.pdf"},"version_id":"67beabc6-eec1-49d7-9c6b-4f768e78c68b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Aminolevulinic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HepG2 cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Apoptosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytochrome C oxidase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mitochondrial membrane permeability\\n","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"HepG2細胞の増殖抑制におけるアミノレブリン酸の効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HepG2細胞の増殖抑制におけるアミノレブリン酸の効果"},{"subitem_title":"Effect of aminolevlinic acid on inhibition of HepG2 cell proliferation","subitem_title_language":"en"}]},"item_type_id":"3","owner":"15","path":["17"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-03-21"},"publish_date":"2013-03-21","publish_status":"0","recid":"166","relation_version_is_last":true,"title":["HepG2細胞の増殖抑制におけるアミノレブリン酸の効果"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-12-19T06:39:40.771224+00:00"}